Hydrochloric Acid → 3-Ethynyl-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one

HRID 2089794Notes

Reaction equation

[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([N:9]2[CH:14]=[CH:13][C:12](=[O:15])[C:11]([C:16]#[C:17][Si](C)(C)C)=[N:10]2)[CH:6]=[CH:7][CH:8]=1.Cl>CO.[OH-].[Na+]>[C:16]([C:11]1[C:12](=[O:15])[CH:13]=[CH:14][N:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:23])([F:22])[F:1])[CH:4]=2)[N:10]=1)#[CH:17]

Participants

Conditions

Temperature: 0 °C

Procedure

A mixture of 1-[3-(trifluoromethyl)phenyl]-3-[(trimethylsilyl)ethynyl]pyridazin-4(1H)-one (148 mg, 0.439 mmol) in MeOH (3 mL) and 1 M NaOH aqueous solution (5 mL) was stirred at 0° C. for 5 min and at room temperature for 2 h. The mixture was neutralized with 1 M HCl aqueous solution at 0° C. The mixture was extracted with EtOAc, washed with brine, dried over Na2SO4, filtered, concentrated in vacuo and purified by column chromatography on silica gel (hexane/EtOAc=50/50 to 0/100) to yield the title compound (69 mg, 59% yield) as a pale red solid: 1H NMR (DMSO-d6, 300 MHz): δ ppm 4.70 (1H, s), 6.65 (1H, d, J=7.9 Hz), 7.76-7.92 (2H, m), 7.99-8.17 (2H, m), 8.93 (1H, d, J=7.9 Hz).

Workup

extractionThe mixture was extracted with EtOAc
washwashed with brine
dry with materialdried over Na2SO4
filtrationfiltered
concentrationconcentrated in vacuo
custompurified by column chromatography on silica gel (hexane/EtOAc=50/50 to 0/100)

Sources & evidence

ORD record: ord-8b486dd7912a4bee9a5d69453b107cf4
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08435995B2

Reaction notes

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