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HRID2090140

反应详情

EQUATION

反应方程式

HRID 2090140 的结构方程式

REACTANTS

反应物

1
结构：CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O.N#CS
HCID83938

Erythromycin thiocyanate

C38H68N2O13S

PRODUCTS

生成物

1
结构：CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
HCID12560

Erythromycin

C37H67NO13

收率 14%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
37 °C

PROCEDURE

实验过程

Erythromycin thiocyanate (200 g) was added into dichloromethane (500 mL), stirred under heat to 37° C. and adjusted to pH 12 until the solution became clear. The upper aqueous phase was separated and removed to obtain a dichloromethane solution with about 14% of erythromycin A. The dichloromethane solution was cooled to 24° C., kept for 2 hours and then cooled to −4° C. in 5 hours. The crystals formed were filtered. Dichloromethane (20 mL) was used to wash the crystals and the crystals were filtered for further 5 minutes. The amount of the erythromycin A in the dried erythromycin is 95.2% with a dichloromethane content of 150 ppm, a water content of 1.0% and a microbiological titre of 948 μ/mg.

WORKUP

后处理

  1. customThe upper aqueous phase was separated
  2. customremoved