Erythromycin Thiocyanate → Erythromycin

Participants

Reaction Conditions

Reaction Steps

Erythromycin thiocyanate (200 g) was added into dichloromethane (500 mL), stirred under heat to 37° C. and adjusted to pH 12 until the solution became clear. The upper aqueous phase was separated and removed to obtain a dichloromethane solution with about 14% of erythromycin A. The dichloromethane solution was cooled to 24° C., kept for 2 hours and then cooled to −4° C. in 5 hours. The crystals formed were filtered. Dichloromethane (20 mL) was used to wash the crystals and the crystals were filtered for further 5 minutes. The amount of the erythromycin A in the dried erythromycin is 95.2% with a dichloromethane content of 150 ppm, a water content of 1.0% and a microbiological titre of 948 μ/mg.

Provenance & Evidence