反应详情

4.00 g (10.69 mmol) 2,2-bis(4-nitrobenzyl)malonic acid were dissolved in 40 ml tetrahydrofuran and added dropwise in a the course of 2 hours to 64.1 ml (64.1 mmol) of a borane-tetrahydrofuran complex 1.0 M solution in tetrahydro-furan. After 19 hours at 25° C., 50 ml water were carefully added. The reaction mixture was then partitioned between ethyl acetate and water; the organic phase was washed repeatedly with water, dried over sodium sulfate, filtered and concentrated by rotary evaporation. The residue, 3.77 g (97%) of a white powder was used without further purification.

1. customThe reaction mixture was then partitioned between ethyl acetate and water
2. washthe organic phase was washed repeatedly with water
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated by rotary evaporation
6. customThe residue, 3.77 g (97%) of a white powder was used without further purification