HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-(tert-Butyldimethylsilyloxy)propyl)-3-nitroquinolin-4-amine → N4-(3-(tert-Butyldimethylsilyloxy)propyl)quinoline-3,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-(tert-Butyldimethylsilyloxy)propyl)-3-nitroquinolin-4-amine | HCID 68429388 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N4-(3-(tert-Butyldimethylsilyloxy)propyl)quinoline-3,4-diamine | HCID 86647172 | — |
Reaction Steps
A mixture of the product from step (i) (8.5 g), iron powder (14 g) in acetic acid was stirred at rt for 3 h the partitioned between EtOAc/water. The organics were separated, washed with saturated NaHCO3 solution, brine, dried and evaporated under reduced pressure, yield 4.85 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436178B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-9a096c20ce294a618e85dd00054c12c5 |
| Source note | uspto-grants-2013_05 |