反应详情

Valeryl chloride was added to a solution of the product from step (ii) (4.85 g) in NMP at rt. The mixture was stirred at rt for 15 min, heated at 100° C. for 6 h, cooled, and partitioned between EtOAc/saturated NaHCO3 solution. The organics were separated washed with water, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with EtOAc, yield 2.15 g.

1. temperatureheated at 100° C. for 6 h
2. temperaturecooled
3. custompartitioned between EtOAc/saturated NaHCO3 solution
4. customThe organics were separated
5. washwashed with water
6. customdried
7. customevaporated under reduced pressure
8. customThe residue was purified by chromatography on silica eluting with EtOAc, yield 2.15 g