Methanol → HCID 25106691, compound

HRID 2090250Notes

Reaction equation

HRID 2090250 reaction equation
S(=O)(=O)(O)O.[NH2:6][C:7]1[C:16]2[N:17]=[C:18]([CH2:42][CH2:43][CH2:44][CH3:45])[N:19]([CH2:20][CH2:21][CH2:22][N:23]([CH2:31][C:32]3[CH:37]=[CH:36][C:35]([CH2:38][C:39]([OH:41])=[O:40])=[CH:34][CH:33]=3)[CH:24]3[CH2:29][CH2:28][N:27]([CH3:30])[CH2:26][CH2:25]3)[C:15]=2[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1.[CH3:46]O>>[NH2:6][C:7]1[C:16]2[N:17]=[C:18]([CH2:42][CH2:43][CH2:44][CH3:45])[N:19]([CH2:20][CH2:21][CH2:22][N:23]([CH2:31][C:32]3[CH:33]=[CH:34][C:35]([CH2:38][C:39]([O:41][CH3:46])=[O:40])=[CH:36][CH:37]=3)[CH:24]3[CH2:25][CH2:26][N:27]([CH3:30])[CH2:28][CH2:29]3)[C:15]=2[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N:8]=1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 68431610HCID 68431610, compound

Product 1

HCID 25106691HCID 25106691, compound

Procedure

Sulfuric acid (1 mL) was added to the product from step (i) (250 mg) in MeOH (10 mL). The mixture was stirred at rt for 15 h, then the solvent evaporated under reduced pressure. The residue was purified by RPHPLC to afford the title compound, yield 6.2 mg.

Workup

  1. customthe solvent evaporated under reduced pressure
  2. customThe residue was purified by RPHPLC

Sources & evidence

ORD record
ord-972886bb661a48428f3f5ca71c52adaa
Source dataset
uspto-grants-2013_05
Patent number
US08436178B2

Reaction notes

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