反应详情

Pentanoyl chloride (3.7 mL) was added dropwise to a stirred solution of the product from step (iii) (10 g) and TEA (5 mL) in NMP (110 mL) at rt under nitrogen. The mixture was stirred at rt for 2 h then heated to 100° C. for 6 h. After cooling, the reaction mixture was partitioned between diethyl ether/water, the organics were separated, washed with water, dried, and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 50-70% EtOAc/isohexane, yield 6.58 g.

1. temperaturethen heated to 100° C. for 6 h
2. temperatureAfter cooling
3. customthe reaction mixture was partitioned between diethyl ether/water
4. customthe organics were separated
5. washwashed with water
6. customdried
7. customevaporated under reduced pressure
8. customThe residue was purified by chromatography on silica eluting with 50-70% EtOAc/isohexane, yield 6.58 g