反应详情

To the product from step (v) (180 mg) in MeCN (5 mL), 2-chloroacetyl chloride (44.0 mg) was added at 0° C. and stirred for 7 h. Piperidine (332 mg) was added and stirred at rt for 15 h. The solvent was removed and the crude product was purified by RPHPLC. The resulting residue was triturated with diethyl ether to afford the title compound as a white solid (22 mg).

1. stirringstirred at rt for 15 h
2. customThe solvent was removed
3. customthe crude product was purified by RPHPLC
4. customThe resulting residue was triturated with diethyl ether