HRID2090266

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID674

Dimethylamine

C2H7N

HCID8028

Tetrahydrofuran

C4H8O

结构：COCCc1nc2c(N)nc3ccccc3c2n1CCCNCc1ccc(CC(=O)OC)cc1

HCID68430910

未命名化合物

PRODUCTS

生成物

结构：COCCc1nc2c(N)nc3ccccc3c2n1CCCN(Cc1ccc(CC(=O)OC)cc1)C(=O)CN(C)C

HCID25107143

未命名化合物

PROCEDURE

实验过程

The title compound was prepared by the method of example 29 step (vi) with the product of example 29 step (v) (180 mg) and a 2M THF solution of dimethylamine (0.2 ml). The title compound was obtained as a white solid (15 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a23e00ee85d04dd291673126c4f75d55
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436178B2
来源说明: uspto-grants-2013_05

反应 SMILES

[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:31][CH2:32][O:33][CH3:34])[N:14]([CH2:15][CH2:16][CH2:17][NH:18][CH2:19][C:20]3[CH:25]=[CH:24][C:23]([CH2:26][C:27]([O:29][CH3:30])=[O:28])=[CH:22][CH:21]=3)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[CH3:35][NH:36][CH3:37].C1C[O:41][CH2:40][CH2:39]1>>[NH2:1][C:2]1[C:11]2[N:12]=[C:13]([CH2:31][CH2:32][O:33][CH3:34])[N:14]([CH2:15][CH2:16][CH2:17][N:18]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([CH2:26][C:27]([O:29][CH3:30])=[O:28])=[CH:24][CH:25]=3)[C:40](=[O:41])[CH2:39][N:36]([CH3:37])[CH3:35])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1