2-Chloro-4-hydroxybenzonitrile → HCID 46701320, compound

HRID 2090307Notes

Reaction equation

HRID 2090307 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([C:12]3[CH:17]=[C:16]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[N:15]=[C:14]([NH2:25])[N:13]=3)[CH2:9]2)=[CH:4][CH:3]=1.[Cl:26][C:27]1[CH:34]=[C:33]([OH:35])[CH:32]=[CH:31][C:28]=1[C:29]#[N:30]>>[NH2:25][C:14]1[N:13]=[C:12]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][C:2]([O:35][C:33]4[CH:32]=[CH:31][C:28]([C:29]#[N:30])=[C:27]([Cl:26])[CH:34]=4)=[CH:3][CH:4]=3)[CH2:9]2)[CH:17]=[C:16]([N:18]2[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]2)[N:15]=1

Participants

3

Reactant 2

HCID 5927972-Chloro-4-hydroxybenzonitrileHCID 467010484-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine

Product 1

HCID 46701320HCID 46701320, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 17 starting from 4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and 2-chloro-4-hydroxybenzonitrile (Aldrich, Cat. No. 346071). LCMS (M+H)+: m/z=476.3.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-becbfede63b5494a9f51aa9a408d7004
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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