Pyrrolidine → 4-(4-Methylpiperazin-1-yl)-6-[7-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

HRID 2090315Notes

Reaction equation

HRID 2090315 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18]([OH:20])=O)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:21]2[CH2:26][CH2:25][N:24]([CH3:27])[CH2:23][CH2:22]2)[N:3]=1.[NH:28]1[CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH3:27][N:24]1[CH2:23][CH2:22][N:21]([C:4]2[CH:5]=[C:6]([N:8]3[CH2:17][CH2:16][C:15]4[C:10](=[CH:11][C:12]([C:18]([N:28]5[CH2:32][CH2:31][CH2:30][CH2:29]5)=[O:20])=[CH:13][CH:14]=4)[CH2:9]3)[N:7]=[C:2]([NH2:1])[N:3]=2)[CH2:26][CH2:25]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 594022702-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

Product 1

HCID 467013884-(4-Methylpiperazin-1-yl)-6-[7-(pyrrolidin-1-ylcarbonyl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 18 starting from 2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid and pyrrolidine (Aldrich Cat. No. P73803). LCMS (M+H)+: m/z=422.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-7efec8926d6a47cd9f89c857a603a467
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

Loading…