4-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine → HCID 59402261, compound

HRID 2090334Notes

Reaction equation

HRID 2090334 reaction equation
Br[C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH:7](C)[N:8]([C:12]3[CH:17]=[C:16]([N:18]4[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]4)[N:15]=[C:14]([NH2:25])[N:13]=3)[CH2:9]2)=[CH:4][CH:3]=1.[C:27]([C:29]1[N:34]=[CH:33][C:32](B(O)O)=[CH:31][C:30]=1[CH3:38])#[N:28]>>[NH2:25][C:14]1[N:13]=[C:12]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][C:2]([C:32]4[CH:31]=[C:30]([CH3:38])[C:29]([C:27]#[N:28])=[N:34][CH:33]=4)=[CH:3][CH:4]=3)[CH2:9]2)[CH:17]=[C:16]([N:18]2[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]2)[N:15]=1

Participants

3

Reactant 2

HCID 594023174-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amineHCID 68472207HCID 68472207, compound

Product 1

HCID 59402261HCID 59402261, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 2 starting from 4-(7-bromo-3-methyl-3,4-dihydroisoquinolin-2(1H)-yl)-6-(4-methylpiperazin-1-yl)pyrimidin-2-amine and (6-cyano-5-methylpyridin-3-yl)boronic acid (Combi-Blocks, Cat. No. PN-5814). LCMS (M+H)+: m/z=441.1.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-edd4fab5a83d403d87cd8d3141000280
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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