Pyrrolidine → HCID 46701588, compound

HRID 2090338Notes

Reaction equation

HRID 2090338 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:18]4[S:19][CH:20]=[C:21]([C:23]([O:25]CC)=O)[N:22]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:28]2[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]2)[N:3]=1.[NH:35]1[CH2:39][CH2:38][CH2:37][CH2:36]1>>[CH3:34][N:31]1[CH2:30][CH2:29][N:28]([C:4]2[CH:5]=[C:6]([N:8]3[CH2:17][CH2:16][C:15]4[C:10](=[CH:11][C:12]([C:18]5[S:19][CH:20]=[C:21]([C:23]([N:35]6[CH2:39][CH2:38][CH2:37][CH2:36]6)=[O:25])[N:22]=5)=[CH:13][CH:14]=4)[CH2:9]3)[N:7]=[C:2]([NH2:1])[N:3]=2)[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 59402308HCID 59402308, compound

Product 1

HCID 46701588HCID 46701588, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 47 starting from ethyl 2-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydro isoquinolin-7-yl}-1,3-thiazole-4-carboxylate and pyrrolidine. LCMS (M+H)+: m/z=505.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-771b16bf32594e8280687085ba13f02d
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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