Dimethylamine, hydrochloride → HCID 59402366, compound

HRID 2090379Notes

Reaction equation

C([O:5][C:6](=O)[CH2:7][N:8]1[CH:12]=[C:11]([C:13]2[CH:22]=[C:21]3[C:16]([CH2:17][CH:18]([CH3:37])[N:19]([C:23]4[CH:28]=[C:27]([N:29]5[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]5)[N:26]=[C:25]([NH2:36])[N:24]=4)[CH2:20]3)=[CH:15][CH:14]=2)[CH:10]=[N:9]1)(C)(C)C.Cl.[CH3:40][NH:41][CH3:42]>>[NH2:36][C:25]1[N:24]=[C:23]([N:19]2[CH:18]([CH3:37])[CH2:17][C:16]3[C:21](=[CH:22][C:13]([C:11]4[CH:10]=[N:9][N:8]([CH2:7][C:6]([N:41]([CH3:42])[CH3:40])=[O:5])[CH:12]=4)=[CH:14][CH:15]=3)[CH2:20]2)[CH:28]=[C:27]([N:29]2[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]2)[N:26]=1

Participants

Reactant 2

HCID 10473Dimethylamine, hydrochloride

HCID 59402340HCID 59402340, compound

Product 1

HCID 59402366HCID 59402366, compound

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 79 starting from tert-butyl(4-{2-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-1H-pyrazol-1-yl)acetate and dimethylamine hydrochloride. LCMS (M+H)+: m/z=490.3.

Workup

customThis compound was prepared

Sources & evidence

ORD record: ord-9d5e02aaaeed476080b45da0bad56ec3
Source dataset: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08436008B2

Reaction notes

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