Benzyl Alcohol → HCID 59402320, compound

HRID 2090397Notes

Reaction equation

HRID 2090397 reaction equation
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([I:10])[CH:9]=1)=[O:4].[CH2:13]([OH:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(N(CC)CC)C>>[I:10][C:8]1[CH:9]=[C:5]([C:3]([O:20][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:4])[NH:6][CH:7]=1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 8471TriethylamineHCID 116816022,2,2-trichloro-1-(4-iodo-1H-pyrrol-2-yl)ethan-1-one

Product 1

HCID 59402320HCID 59402320, compound

Conditions

Temperature
60 °C

Procedure

A mixture of 2,2,2-trichloro-1-(4-iodo-1H-pyrrol-2-yl)ethanone (4.0 g, 12 mmol), benzyl alcohol (9.0 mL, 87 mmol), and triethylamine (2.5 mL, 18 mmol) in a round flask was heated at 60° C. with stirring for 2 h. After cooling, the volatiles were removed under reduced pressure to afford the crude product which was directly used in the next reaction without further purification.

Workup

  1. temperatureAfter cooling
  2. customthe volatiles were removed under reduced pressure

Sources & evidence

ORD record
ord-3c96ecd7afcc490c88c6536828faee39
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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