Trifluoroacetic acid → HCID 59402278, compound

HRID 2090457Notes

Reaction equation

HRID 2090457 reaction equation
C(O)(C(F)(F)F)=O.Cl[C:9]1[CH:14]=[C:13]([N:15]2[CH:24]([CH3:25])[CH2:23][C:22]3[C:17](=[CH:18][C:19]([C:26]4[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=4)=[CH:20][CH:21]=3)[CH2:16]2)[N:12]=[C:11]([NH2:32])[N:10]=1.[NH:33]1[CH2:38][CH2:37][CH:36]([NH:39]C(=O)OC(C)(C)C)[CH2:35][CH2:34]1>>[NH2:39][CH:36]1[CH2:37][CH2:38][N:33]([C:9]2[CH:14]=[C:13]([N:15]3[CH:24]([CH3:25])[CH2:23][C:22]4[C:17](=[CH:18][C:19]([C:26]5[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=5)=[CH:20][CH:21]=4)[CH2:16]3)[N:12]=[C:11]([NH2:32])[N:10]=2)[CH2:34][CH2:35]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7238334-(N-Boc-amino)piperidineHCID 59402369HCID 59402369, compound

Product 1

HCID 59402278HCID 59402278, compound

Procedure

This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 118 starting from 4-chloro-6-[3-methyl-7-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine and tert-butyl piperidin-4-ylcarbamate (Aldrich, Cat. No. 540935). LCMS (M+H)+: m/z=419.2.

Sources & evidence

ORD record
ord-0047fdb2492c447ca6ab1ca216848292
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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