Trifluoroacetic acid → HCID 59402289, compound

HRID 2090458Notes

Reaction equation

HRID 2090458 reaction equation
C(O)(C(F)(F)F)=O.Cl[C:9]1[CH:14]=[C:13]([N:15]2[CH:24]([CH3:25])[CH2:23][C:22]3[C:17](=[CH:18][C:19]([C:26]4[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=4)=[CH:20][CH:21]=3)[CH2:16]2)[N:12]=[C:11]([NH2:32])[N:10]=1.[N:33]1(C(OC(C)(C)C)=O)[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[CH3:25][CH:24]1[CH2:23][C:22]2[C:17](=[CH:18][C:19]([C:26]3[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=3)=[CH:20][CH:21]=2)[CH2:16][N:15]1[C:13]1[CH:14]=[C:9]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)[N:10]=[C:11]([NH2:32])[N:12]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 143452tert-Butyl piperazine-1-carboxylateHCID 59402369HCID 59402369, compound

Product 1

HCID 59402289HCID 59402289, compound

Procedure

This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 118 starting from 4-chloro-6-[3-methyl-7-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine and tert-butyl piperazine-1-carboxylate (Aldrich, Cat. No. 343536). LCMS (M+H)+: m/z=405.2.

Sources & evidence

ORD record
ord-197ce8aedbcb43a9862c75a29d463db2
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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