Trifluoroacetic acid → HCID 46701916, compound

HRID 2090460Notes

Reaction equation

HRID 2090460 reaction equation
C(O)(C(F)(F)F)=O.Cl[C:9]1[CH:14]=[C:13]([N:15]2[CH:24]([CH3:25])[CH2:23][C:22]3[C:17](=[CH:18][C:19]([C:26]4[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=4)=[CH:20][CH:21]=3)[CH2:16]2)[N:12]=[C:11]([NH2:32])[N:10]=1.[CH:33]12[CH2:39][CH:36]([NH:37][CH2:38]1)[CH2:35][N:34]2C(OC(C)(C)C)=O>>[CH:33]12[CH2:39][CH:36]([NH:37][CH2:38]1)[CH2:35][N:34]2[C:9]1[CH:14]=[C:13]([N:15]2[CH:24]([CH3:25])[CH2:23][C:22]3[C:17](=[CH:18][C:19]([C:26]4[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=4)=[CH:20][CH:21]=3)[CH2:16]2)[N:12]=[C:11]([NH2:32])[N:10]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 2760898(1S,4S)-tert-butyl 2,5-diazabicyclo(2.2.1)heptane-2-carboxylateHCID 59402369HCID 59402369, compound

Product 1

HCID 46701916HCID 46701916, compound

Procedure

This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 118 starting from 4-chloro-6-[3-methyl-7-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine and tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (Alfa Aesar, Cat. No. L20131). LCMS (M+H)+: m/z=417.2.

Sources & evidence

ORD record
ord-0472d798e58f42748579432e6c5f30a4
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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