Trifluoroacetic acid → HCID 59402393, compound

HRID 2090462Notes

Reaction equation

HRID 2090462 reaction equation
C(O)(C(F)(F)F)=O.Cl[C:9]1[CH:14]=[C:13]([N:15]2[CH:24]([CH3:25])[CH2:23][C:22]3[C:17](=[CH:18][C:19]([C:26]4[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=4)=[CH:20][CH:21]=3)[CH2:16]2)[N:12]=[C:11]([NH2:32])[N:10]=1.[CH3:33][N:34]([C@@H:42]1[CH2:46][CH2:45][NH:44][CH2:43]1)C(=O)OC(C)(C)C>>[CH3:33][NH:34][C@@H:42]1[CH2:46][CH2:45][N:44]([C:9]2[CH:14]=[C:13]([N:15]3[CH:24]([CH3:25])[CH2:23][C:22]4[C:17](=[CH:18][C:19]([C:26]5[CH:27]=[N:28][N:29]([CH3:31])[CH:30]=5)=[CH:20][CH:21]=4)[CH2:16]3)[N:12]=[C:11]([NH2:32])[N:10]=2)[CH2:43]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7019173tert-Butyl methyl((3R)-pyrrolidin-3-yl)carbamateHCID 59402369HCID 59402369, compound

Product 1

HCID 59402393HCID 59402393, compound

Procedure

This compound was prepared as TFA salt by using procedures analogous to those described for the synthesis of Example 118 starting from 4-chloro-6-[3-methyl-7-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine and tert-butyl methyl[(3R)-pyrrolidin-3-yl]carbamate. LCMS (M+H)+: m/z=419.2.

Sources & evidence

ORD record
ord-3d0c5b07555d41129e92b8a18bf3f9d6
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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