Dimethylamine → HCID 59402283, compound

HRID 2090478Notes

Reaction equation

HRID 2090478 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH:17]([CH3:18])[CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:19]4[S:20][C:21]([C:24](O)=[O:25])=[CH:22][N:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)[N:3]=1.[CH3:34][NH:35][CH3:36]>O1CCCC1>[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[CH:17]([CH3:18])[CH2:16][C:15]3[C:10](=[CH:11][C:12]([C:19]4[S:20][C:21]([C:24]([N:35]([CH3:36])[CH3:34])=[O:25])=[CH:22][N:23]=4)=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[C:4]([N:27]2[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]2)[N:3]=1

Participants

4

Reactant 2

HCID 674DimethylamineHCID 59402253HCID 59402253, compound

Product 1

HCID 59402283HCID 59402283, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound was prepared by using procedures analogous to those described for the synthesis of Example 133 starting from 2-{2-[2-amino-6-(4-methylpiperazin-l-yl)pyrimidin-4-yl]-3-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}-1,3-thiazole-5-carboxylic acid and 2.0 M of dimethylamine in tetrahydrofuran solution. LCMS (M+H)+: m/z=493.2.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-402ecea0838c49b3a36ce4fcb78013a2
Source dataset
uspto-grants-2013_05
Patent number
US08436008B2

Reaction notes

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