HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 178478255, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 178451927 | HCID 178451927 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 178478255 | HCID 178478255 | — |
Reaction Steps
First, to a solution of (S)-tert-butyl 2-(5-(3-(4-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate in dichloromethane, excess HCl (1M in isopropanol) was added dropwise. The precipitated solid was filtered off and dried in the vacuum oven to afford 2-(pyrrolidin-2-yl)-5-(4-(3-(2-(pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazole hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436036B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-35c849e560db405d9c0ffccf71497567 |
| Source note | uspto-grants-2013_05 |