Dichloromethane → HCID 178478255, compound

HRID 2090551Notes

Reaction equation

HRID 2090551 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][C@H:9]1[C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:47]=[CH:46][C:21]([O:22][C:23]3[CH:24]=[C:25]([C:29]4[NH:33][C:32]([C@@H:34]5[CH2:38][CH2:37][CH2:36][N:35]5C(OC(C)(C)C)=O)=[N:31][CH:30]=4)[CH:26]=[CH:27][CH:28]=3)=[CH:20][CH:19]=2)[N:17]=1)=O)(C)(C)C.[Cl:48]CCl>Cl>[ClH:48].[NH:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[NH:17][C:16]([C:18]2[CH:47]=[CH:46][C:21]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([C:29]4[N:33]=[C:32]([CH:34]5[CH2:38][CH2:37][CH2:36][NH:35]5)[NH:31][CH:30]=4)[CH:24]=3)=[CH:20][CH:19]=2)=[CH:15][N:14]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 178451927HCID 178451927, compound

Product 1

HCID 178478255HCID 178478255, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

First, to a solution of (S)-tert-butyl 2-(5-(3-(4-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate in dichloromethane, excess HCl (1M in isopropanol) was added dropwise. The precipitated solid was filtered off and dried in the vacuum oven to afford 2-(pyrrolidin-2-yl)-5-(4-(3-(2-(pyrrolidin-2-yl)-1H-imidazol-4-yl)phenoxy)phenyl)-1H-imidazole hydrochloride.

Workup

  1. filtrationThe precipitated solid was filtered off
  2. customdried in the vacuum oven

Sources & evidence

ORD record
ord-35c849e560db405d9c0ffccf71497567
Source dataset
uspto-grants-2013_05
Patent number
US08436036B2

Reaction notes

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