Dimethyl Sulfoxide → 2-(7-Methoxynaphthalen-1-yl)acetonitrile

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound obtained in Step B (100 g) in 30 ml/g of DMSO and 5 ml/g of water there are added 1.2 equivalents of potassium cyanide (37.8 g). The reaction mixture is heated to 65° C. and maintained at 65° C. for 3 hours. After returning to ambient temperature, an MTBE/water (1/1) binary system is added to the mixture. The aqueous phase is removed. The organic phase is washed several times with water and then with saturated NaCl solution. The solvents are distilled off and the title compound is obtained in a quantitative yield.

Provenance & Evidence