反应详情

温度

65 °C

To a solution of the compound obtained in Step B (100 g) in 30 ml/g of DMSO and 5 ml/g of water there are added 1.2 equivalents of potassium cyanide (37.8 g). The reaction mixture is heated to 65° C. and maintained at 65° C. for 3 hours. After returning to ambient temperature, an MTBE/water (1/1) binary system is added to the mixture. The aqueous phase is removed. The organic phase is washed several times with water and then with saturated NaCl solution. The solvents are distilled off and the title compound is obtained in a quantitative yield.

1. temperaturemaintained at 65° C. for 3 hours
2. customAfter returning to ambient temperature
3. customThe aqueous phase is removed
4. washThe organic phase is washed several times with water
5. distillationThe solvents are distilled off