反应详情

tert-butyl 4-(4-(pyrrolidin-1-yl)quinazolin-7-yl)piperazine-1-carboxylate (B) (130 mg, 0.339 mmol) was dissolved at room temperature in methanol (2 ml), and then hydrogen chloride (2.71 ml, 3.39 mmol, 1.25 M solution in methanol) was added. The reaction mixture was refluxed for 1 h and then stirred for 15 h at room temperature. Concentration in vacuo was carried out, and the residue was taken up in a small amount of ethanol and heated. Diethyl ether was then added, the mixture was cooled in an ice bath, and finally the resulting solid was filtered off.

1. temperatureThe reaction mixture was refluxed for 1 h
2. concentrationConcentration in vacuo
3. temperatureheated
4. additionDiethyl ether was then added
5. temperaturethe mixture was cooled in an ice bath
6. filtrationfinally the resulting solid was filtered off