Trifluoroacetic acid → HCID 59746453, compound

HRID 2090817Notes

Reaction equation

HRID 2090817 reaction equation
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([S:17]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH:21]2[CH2:26][O:27][CH2:28][C:29]([N:31]2[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32]2)=[O:30])(=[O:19])=[O:18])=[C:12]([CH3:44])[CH:11]=1>ClCCl>[CH3:8][O:9][C:10]1[CH:15]=[C:14]([CH3:16])[C:13]([S:17]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH:21]2[CH2:26][O:27][CH2:28][C:29]([N:31]2[CH2:32][CH2:33][NH:34][CH2:35][CH2:36]2)=[O:30])(=[O:18])=[O:19])=[C:12]([CH3:44])[CH:11]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59746481HCID 59746481, compound

Product 1

HCID 59746453HCID 59746453, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (13 eq.) was added at 0° C. to a solution of tert-butyl 4-(2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetyl)piperazine-1-carboxylate (Example 101) (1 eq.) in dichloromethane (10 ml/mmol). The reaction mixture was stirred for 2 h at room temperature and then concentrated in vacuo. The crude product was used in the next synthesis step without being purified further.

Workup

  1. concentrationconcentrated in vacuo
  2. customThe crude product was used in the next synthesis step
  3. customwithout being purified further

Sources & evidence

ORD record
ord-3ccbde117ca24ee0ad3337c6acffe126
Source dataset
uspto-grants-2013_05
Patent number
US08435978B2

Reaction notes

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