Hydrazine hydrate (1:1) → HCID 178469919, compound

Participants

Reaction Steps

Using ethyl 3-oxo-5-phenylpentanoate (5.8 g), dimethylformamide dimethylacetal (3.6 mL) and hydrazine monohydrate (1.3 mL) and in the same manner as in Example 1(3), a crude product of ethyl 3-(2-phenylethyl)-1H-pyrazole-4-carboxylate was obtained. This was dissolved in dimethylformamide (30 ml), potassium carbonate (5.5 g) and 2-chloro-5-trifluoromethylpyridine (4.8 g) were added, and the mixture was stirred at 100° C. overnight. In the same manner as in Example 1(4), the title object compound (5.2 g, 50%) was obtained as a white solid.

Provenance & Evidence