Hydrazine hydrate (1:1) → HCID 178498887, compound

Participants

Reaction Steps

Using ethyl 4,4-dimethyl-3-oxopentanoate (3.4 g), dimethylformamide dimethylacetal (2.8 mL) and hydrazine monohydrate (1.1 mL), and in the same manner as in Example 1(3), a crude product of methyl 3-tert-butyl-1H-pyrazole-4-carboxylate was obtained. This was dissolved in dimethylformamide (15 ml), potassium carbonate (1.2 g) and 2-chloro-5-trifluoromethylpyridine (1.7 g) were added, and the mixture was stirred at room temperature overnight. In the same manner as in Example 1(4), the title object compound (2.8 g, 43%) was obtained as a white solid.

Provenance & Evidence