Hydrazine hydrate (1:1) → HCID 178498887, compound
Reaction equation
[CH3:1][C:2]([CH3:12])([CH3:11])[C:3](=O)[CH2:4][C:5]([O:7][CH2:8]C)=[O:6].COC(OC)[N:16]([CH3:18])C.O.[NH2:22]N>>[C:2]([C:3]1[C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:18][NH:16][N:22]=1)([CH3:12])([CH3:11])[CH3:1]Participants
4
Procedure
Using ethyl 4,4-dimethyl-3-oxopentanoate (3.4 g), dimethylformamide dimethylacetal (2.8 mL) and hydrazine monohydrate (1.1 mL), and in the same manner as in Example 1(3), a crude product of methyl 3-tert-butyl-1H-pyrazole-4-carboxylate was obtained. This was dissolved in dimethylformamide (15 ml), potassium carbonate (1.2 g) and 2-chloro-5-trifluoromethylpyridine (1.7 g) were added, and the mixture was stirred at room temperature overnight. In the same manner as in Example 1(4), the title object compound (2.8 g, 43%) was obtained as a white solid.
Sources & evidence
- ORD record
- ord-3e30974055174131ae5f6f80a157b25b
- Source dataset
- uspto-grants-2013_05
- Patent number
- US08436043B2
Reaction notes
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