(4-Fluoro-2-methylphenyl)boronic acid → methyl 1-(4-fluoro-2-methylphenyl)-3-methyl-1H-pyrazole-4-carboxylate

HRID 2090859Notes

Reaction equation

HRID 2090859 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][NH:4][N:3]=1.[F:11][C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[C:14]([CH3:21])[CH:13]=1>>[F:11][C:12]1[CH:17]=[CH:16][C:15]([N:4]2[CH:5]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:2]([CH3:1])=[N:3]2)=[C:14]([CH3:21])[CH:13]=1

Participants

3

Reactant 2

HCID 2734665(4-Fluoro-2-methylphenyl)boronic acidHCID 178498883HCID 178498883, compound

Product 1

HCID 66777491methyl 1-(4-fluoro-2-methylphenyl)-3-methyl-1H-pyrazole-4-carboxylateYield 68%

Procedure

Using methyl 3-methyl-1H-pyrazole-4-carboxylate (6.25 g) synthesized in Example 1(3) and 4-fluoro-2-methylphenylboronic acid (13.9 g) and in the same manner as in Example 17(1), the title object compound (7.5 g, 68%) was obtained as a white solid.

Sources & evidence

ORD record
ord-385acdb7d6dd4afab7b80362171e31f3
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

Loading…