(4-Methoxyphenyl)boronic acid → methyl 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-4-carboxylate

HRID 2090862Notes

Reaction equation

HRID 2090862 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][NH:4][N:3]=1.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([N:4]2[CH:5]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:2]([CH3:1])=[N:3]2)=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 178498883HCID 178498883, compound

Product 1

HCID 66777993methyl 1-(4-methoxyphenyl)-3-methyl-1H-pyrazole-4-carboxylateYield 65%

Procedure

Using methyl 3-methyl-1H-pyrazole-4-carboxylate (5.7 g) synthesized in Example 1(3) and 4-methoxyphenylboronic acid (12.4 g) and in the same manner as in Example 17(1), the title object compound (6.5 g, 65%) was obtained as a white solid.

Sources & evidence

ORD record
ord-7398a818e4ed4e87a901dc6cc348b4e9
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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