2,3-Dichloro-5-(trifluoromethyl)pyridine → methyl 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-3-methyl-1H-pyrazole-4-carboxylate

HRID 2090875Notes

Reaction equation

HRID 2090875 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][NH:4][N:3]=1.Cl[C:12]1[C:17]([Cl:18])=[CH:16][C:15]([C:19]([F:22])([F:21])[F:20])=[CH:14][N:13]=1>>[Cl:18][C:17]1[C:12]([N:4]2[CH:5]=[C:6]([C:7]([O:9][CH3:10])=[O:8])[C:2]([CH3:1])=[N:3]2)=[N:13][CH:14]=[C:15]([C:19]([F:21])([F:20])[F:22])[CH:16]=1

Participants

3

Reactant 2

HCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridineHCID 178498883HCID 178498883, compound

Product 1

HCID 66778425methyl 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-3-methyl-1H-pyrazole-4-carboxylateYield 81.5%

Procedure

Using methyl 3-methyl-1H-pyrazole-4-carboxylate (3.8 g) synthesized in Example 1(3) and 2,3-dichloro-5-trifluoromethylpyridine (5.8 g) and in the same manner as in Example 1(4), the title object compound (7.0 g, 78%) was obtained as a pale-yellow solid.

Sources & evidence

ORD record
ord-dbe52f27ff264020ad2e152b123fe3bc
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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