Dimethylformamide dimethyl acetal → HCID 66777503, compound

HRID 2090894Notes

Reaction equation

HRID 2090894 reaction equation
[CH:1]1([C:4](=O)[CH2:5][C:6]([O:8][CH3:9])=[O:7])[CH2:3][CH2:2]1.[CH3:11]OC(OC)N(C)C.O.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([NH:28][NH2:29])=[CH:24][CH:23]=1>>[CH:1]1([C:4]2[C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:11][N:28]([C:25]3[CH:26]=[CH:27][C:22]([O:21][CH3:20])=[CH:23][CH:24]=3)[N:29]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 78373Dimethylformamide dimethyl acetalHCID 101300163-Cyclopropyl-3-Oxopropionic Acid Methyl EsterHCID 66778904HCID 66778904, compound

Product 1

HCID 66777503HCID 66777503, compoundYield 84%

Procedure

Using methyl 3-cyclopropyl-3-oxopropanoate (3.7 g), dimethylformamide dimethylacetal (3.6 mL) and p-methoxyphenylhydrazine monohydrate (4.7 g) and in the same manner as in Example 15(1), the title object compound (5.9 g, 84%) was obtained as an oil.

Sources & evidence

ORD record
ord-f4602db0f5b24dc8ab4833850633b453
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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