HRID2090914

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID46941342

未命名化合物

结构：CCn1nc(-c2ccc(OC(F)(F)F)cc2)cc1C(O)CC(C)C

HCID68629236

未命名化合物

PRODUCTS

生成物

结构：CCn1nc(-c2ccc(OC(F)(F)F)cc2)cc1C(CC(C)C)Nc1ccc(C(=O)N(C)CCC(=O)O)cc1

HCID68627772

未命名化合物

收率 4%

PROCEDURE

实验过程

Using 1-{1-ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}-3-methylbutan-1-ol (0.39 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.28 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (0.02 g, 4%) was obtained as a white solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1332f24549bc4da880e8002d0b1dda65
来源数据集: uspto-grants-2013_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08436043B2
来源说明: uspto-grants-2013_05

反应 SMILES

[CH2:1]([N:3]1[C:7]([CH:8](O)[CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)=[N:4]1)[CH3:2].[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([N:34]([CH3:42])[CH2:35][CH2:36][C:37]([O:39]CC)=[O:38])=[O:33])=[CH:28][CH:27]=1>>[CH2:1]([N:3]1[C:7]([CH:8]([NH:25][C:26]2[CH:27]=[CH:28][C:29]([C:32]([N:34]([CH3:42])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])=[O:33])=[CH:30][CH:31]=2)[CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)=[N:4]1)[CH3:2]