Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → 3-[({4-[(1-{1-ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}-3-methylbutyl)amino]phenyl}carbonyl)(methyl)amino]propanoic acid

HRID 2090914Notes

Reaction equation

HRID 2090914 reaction equation
[CH2:1]([N:3]1[C:7]([CH:8](O)[CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)=[N:4]1)[CH3:2].[NH2:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([N:34]([CH3:42])[CH2:35][CH2:36][C:37]([O:39]CC)=[O:38])=[O:33])=[CH:28][CH:27]=1>>[CH2:1]([N:3]1[C:7]([CH:8]([NH:25][C:26]2[CH:27]=[CH:28][C:29]([C:32]([N:34]([CH3:42])[CH2:35][CH2:36][C:37]([OH:39])=[O:38])=[O:33])=[CH:30][CH:31]=2)[CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:6][C:5]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)=[N:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 686292361-{1-ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}-3-methylbutan-1-ol

Product 1

HCID 686277723-[({4-[(1-{1-ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}-3-methylbutyl)amino]phenyl}carbonyl)(methyl)amino]propanoic acidYield 4%

Procedure

Using 1-{1-ethyl-3-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-5-yl}-3-methylbutan-1-ol (0.39 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.28 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (0.02 g, 4%) was obtained as a white solid.

Sources & evidence

ORD record
ord-1332f24549bc4da880e8002d0b1dda65
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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