反应详情

To a mixture of 5-methoxy-3-methyl-1-benzofuran (1.87 g) synthesized in Example A104(2), heptanoyl chloride (2.14 mL) and nitromethane (20 mL) was added aluminum chloride (3.07 g), and the mixture was stirred overnight at room temperature. Water was added to quench the reaction, and the reaction mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (7% ethyl acetate/hexane) to give the title object compound (2.34 g, 74%) as a pale-yellow solid.

1. customto quench
2. customthe reaction
3. extractionthe reaction mixture was extracted with ethyl acetate
4. washThe extract was washed with saturated brine
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified by silica gel column chromatography (7% ethyl acetate/hexane)