反应详情

To a solution (30 mL) of [5-(benzyloxy)-3-methyl-1-benzofuran-2-yl]methanol (2.8 g) synthesized in the above-mentioned (2) in toluene was added manganese dioxide (5 g), and the mixture was heated under reflux with a Dean-Stark trap for 1 hr. The reaction mixture was allowed to cool to room temperature, catalyst was filtered through celite. The filtrate was concentrated under reduced pressure to give the title object compound (2.68 g, 94%) as a colorless solid.

1. temperaturethe mixture was heated
2. temperatureunder reflux with a Dean-Stark trap for 1 hr
3. filtrationcatalyst was filtered through celite
4. concentrationThe filtrate was concentrated under reduced pressure