[5-(Benzyloxy)-3-methyl-1-benzofuran-2-yl]methanol → 5-(Benzyloxy)-3-methyl-1-benzofuran-2-carbaldehyde

Participants

Reaction Steps

To a solution (30 mL) of [5-(benzyloxy)-3-methyl-1-benzofuran-2-yl]methanol (2.8 g) synthesized in the above-mentioned (2) in toluene was added manganese dioxide (5 g), and the mixture was heated under reflux with a Dean-Stark trap for 1 hr. The reaction mixture was allowed to cool to room temperature, catalyst was filtered through celite. The filtrate was concentrated under reduced pressure to give the title object compound (2.68 g, 94%) as a colorless solid.

Provenance & Evidence