HCID 70654479, compound → HCID 70654759, compound

Participants

Reaction Steps

General method C was applied to (S)-3-methyl-8-(4,4,5,5-tetra methyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one (303 mg, 0.7 mmol) and 4-(6-amino-5-bromopyridin-3-yl)-N-cyclopropylbenzenesulfonamide to give (S)-4-(6-amino-5-(3-methyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)pyridin-3-yl)-N-cyclopropylbenzenesulfonamide as a yellow solid (180 mg, 33% yield) after purification by reverse phase preparatory HPLC. MS (EI) m/z=464.6 [M+1]+.

Provenance & Evidence