HCID 58035654, compound → HCID 58035656, compound

HRID 2091622Notes

Reaction equation

HRID 2091622 reaction equation
[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[CH:10]=[CH:11][C:12]([F:21])=[C:13]([CH:20]=3)[C:14]([O:16]C(C)C)=[O:15])[CH:8]=2)[CH2:3][CH2:2]1>Cl>[CH:1]1([C:4]2[N:5]=[CH:6][N:7]([C:9]3[CH:10]=[CH:11][C:12]([F:21])=[C:13]([CH:20]=3)[C:14]([OH:16])=[O:15])[CH:8]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 58035654HCID 58035654, compound

Product 1

HCID 58035656HCID 58035656, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluorobenzoate (0.306 g, 1.06 mmol) in 2N hydrochloric acid (10 ml) was heated to 100° C. for 10 hours. The solvent was removed under reduced pressure to afford 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluorobenzoic acid as the hydrochloride salt, as a brown powder. (0.260 g, 1.06 mmol). 100% yield. 247 (M+1).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-9932809a71a74b689f31b4584258d6f1
Source dataset
uspto-grants-2013_05
Patent number
US08440665B2

Reaction notes

Loading…