反应详情

3.85 g of trans-2-{4-[N,N-dibenzylamino]cyclohexyl}propan-2-ol (11.40 mmol) was combined with 3.3 g of 20 wt % palladium hydroxide and dissolved with 100 mL of anhydrous ethyl alcohol. The mixture was flushed with H2 (4×) before a H2 balloon was inserted into the reaction and allowed to stir overnight. N2 was bubbled through for about 20 minutes and the catalyst was filtered off. The reaction was washed with methanol. The filtrate was concentrated in vacuo and redissolved in acetonitrile and sonicated which produced a white solid. The mixture was filtered and 0.67 g of white product was obtained (37% yield).

1. customThe mixture was flushed with H2 (4×) before a H2 balloon
2. customwas inserted into the reaction
3. customN2 was bubbled through for about 20 minutes
4. filtrationthe catalyst was filtered off
5. washThe reaction was washed with methanol
6. concentrationThe filtrate was concentrated in vacuo
7. dissolutionredissolved in acetonitrile
8. customsonicated which
9. customproduced a white solid
10. filtrationThe mixture was filtered