Water → 4-Nitrophenyl thiomorpholine-4-carboxylate 1-oxide

HRID 2091759Notes

Reaction equation

HRID 2091759 reaction equation
[N:1]1([C:7]([O:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[CH:12][CH:11]=2)=[O:8])[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.ClC1C=CC=C(C(OO)=[O:27])C=1.O>ClCCl>[N:1]1([C:7]([O:9][C:10]2[CH:11]=[CH:12][C:13]([N+:16]([O-:18])=[O:17])=[CH:14][CH:15]=2)=[O:8])[CH2:2][CH2:3][S:4](=[O:27])[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 962WaterHCID 70297m-Chloroperbenzoic acidHCID 581164954-Nitrophenyl thiomorpholine-4-carboxylate

Product 1

HCID 581165434-Nitrophenyl thiomorpholine-4-carboxylate 1-oxide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

13.1 g (49.0 mmol) of 4-nitrophenyl thiomorpholine-4-carboxylate were initially charged in 135 ml of dichloromethane and admixed at 0° C. with 7.6 g (44.1 mmol) of m-chloroperbenzoic acid in portions. The mixture was stirred at RT for two hours, water was added and the organic phase was removed. The organic phase was washed rapidly with saturated aqueous sodium hydrogencarbonate solution, filtered and concentrated under reduced pressure. The crude product was purified by means of preparative HPLC. Yield: 7.8 g (56% of theory)

Workup

  1. customthe organic phase was removed
  2. washThe organic phase was washed rapidly with saturated aqueous sodium hydrogencarbonate solution
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe crude product was purified by means of preparative HPLC

Sources & evidence

ORD record
ord-a08af7eb85664531b92f7641df160700
Source dataset
uspto-grants-2013_05
Patent number
US08440657B2

Reaction notes

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