Dimethylformamide dimethyl acetal → HCID 72726094, compound

HRID 2091802Notes

Reaction equation

HRID 2091802 reaction equation
[C:1]([CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:5])[CH:2]([CH3:4])[CH3:3].CO[CH:14](OC)[N:15]([CH3:17])[CH3:16]>>[CH2:10]([O:9][C:7](=[O:8])[C:6](=[CH:14][N:15]([CH3:17])[CH3:16])[C:1](=[O:5])[CH:2]([CH3:4])[CH3:3])[CH3:11]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 81583Ethyl isobutyrylacetate

Product 1

HCID 72726094HCID 72726094, compoundYield 50%

Procedure

A mixture of ethyl isobutyrylacetate (15 mmol, 0.42 mL) and N,N-dimethylformamide dimethyl acetal (37.5 mmol, 5 mL) was heated to reflux for 16 hours, then cooled. The volatiles were removed in vacuo to give 1.60 g of 2-dimethylaminomethylene-4-methyl-3-oxo-pentanoic acid ethyl ester.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 16 hours
  3. temperaturecooled
  4. customThe volatiles were removed in vacuo

Sources & evidence

ORD record
ord-df3e091155a14c5ea62f811eee187ed6
Source dataset
uspto-grants-2013_05
Patent number
US08440673B2

Reaction notes

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