2-Aminopyrimidine → HCID 59586803, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of pyrimidin-2-amine (48 mg, 0.50 mmol), 2,4,5-trichloropyrimidine (57 μL, 0.5 mmol), and potassium carbonate (69 mg, 0.5 mmol) in 3 mL of 1,4-dioxane is heated at 110° C. over night. The precipitate is filtered, washed by cold EtOH, and dried in vacuo to afford N-(2,5-Dichloropyrimidin-4-yl)pyrimidin-2-amine; ESMS m/z 242.0 (M+H+).

Provenance & Evidence