2-Aminopyrimidine → HCID 59586803, compound

HRID 2091933Notes

Reaction equation

HRID 2091933 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[NH2:7].[Cl:8][C:9]1[N:14]=[C:13](Cl)[C:12]([Cl:16])=[CH:11][N:10]=1.C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[Cl:8][C:9]1[N:14]=[C:13]([NH:7][C:2]2[N:3]=[CH:4][CH:5]=[CH:6][N:1]=2)[C:12]([Cl:16])=[CH:11][N:10]=1

Participants

5

Reactant 3

HCID 79782-AminopyrimidineHCID 11430Potassium CarbonateHCID 2372592,4,5-Trichloropyrimidine

Product 1

HCID 59586803HCID 59586803, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
110 °C

Procedure

The mixture of pyrimidin-2-amine (48 mg, 0.50 mmol), 2,4,5-trichloropyrimidine (57 μL, 0.5 mmol), and potassium carbonate (69 mg, 0.5 mmol) in 3 mL of 1,4-dioxane is heated at 110° C. over night. The precipitate is filtered, washed by cold EtOH, and dried in vacuo to afford N-(2,5-Dichloropyrimidin-4-yl)pyrimidin-2-amine; ESMS m/z 242.0 (M+H+).

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed by cold EtOH
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e70772a26ad84bf5a3bf400f91dc28df
Source dataset
uspto-grants-2013_05
Patent number
US08440681B2

Reaction notes

Loading…