Sodium Carbonate → HCID 59586806, compound

HRID 2091936Notes

Reaction equation

HRID 2091936 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([NH2:6])=[N:2]1.[Cl:7][C:8]1[N:13]=[C:12](Cl)[C:11]([Cl:15])=[CH:10][N:9]=1.C(=O)([O-])[O-].[Na+].[Na+]>CCO>[Cl:7][C:8]1[N:13]=[C:12]([NH:6][C:3]2[CH:4]=[CH:5][O:1][N:2]=2)[C:11]([Cl:15])=[CH:10][N:9]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 2372592,4,5-TrichloropyrimidineHCID 18102163-Isoxazolamine

Product 1

HCID 59586806HCID 59586806, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The mixture isoxazol-3-amine (36 μL, 0.50 mmol), 2,4,5-trichloropyrimidine (57 μL, 0.5 mmol), and sodium carbonate (53 mg, 0.5 mmol) in 3 mL of EtOH is heated at 60° C. for 48 hrs. The precipitate is filtered, washed by cold EtOH, and dried in vacuo to afford N-(2,5-Dichloropyrimidin-4-yl)isoxazol-3-amine; ESMS m/z 231.0 (M+H+).

Workup

  1. filtrationThe precipitate is filtered
  2. washwashed by cold EtOH
  3. customdried in vacuo

Sources & evidence

ORD record
ord-7809daf6c47f4184aacb7fdcd1a528f8
Source dataset
uspto-grants-2013_05
Patent number
US08440681B2

Reaction notes

Loading…