Hydrazine hydrate (1:1) → 1-(Pyridin-4-yl)ethan-1-amine

HRID 2092013Notes

Reaction equation

HRID 2092013 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([N:9]2C(=O)C3C(=CC=CC=3)C2=O)[CH3:8])=[CH:3][CH:2]=1.O.NN>CO>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([NH2:9])[CH3:8])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 595742662-(1-(Pyridin-4-yl)ethyl)isoindoline-1,3-dione

Product 1

HCID 2479981-(Pyridin-4-yl)ethan-1-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[1-(Pyridin-4-yl)ethyl]isoindoline-1,3-dione (283 mg, 1.12 mmol) in methanol (3 mL) was mixed with hydrazine monohydrate (272 μL, 5.61 mmol) and stirred at room temperature for 16 hours. After completion of the reaction, the solid was filtered off with chloroform, and the filtrate was evaporated under reduced pressure repeatedly to give the desired product.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe solid was filtered off with chloroform
  3. customthe filtrate was evaporated under reduced pressure repeatedly

Sources & evidence

ORD record
ord-a9b0d55083394ee2a7a42317f38ed25c
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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