Hydrazine hydrate (1:1) → HCID 59574214, compound

HRID 2092029Notes

Reaction equation

HRID 2092029 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([N:10]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:8][CH3:9])=[N:3][CH:2]=1.O.NN>CO>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([NH2:10])[CH2:8][CH3:9])=[N:3][CH:2]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59574259HCID 59574259, compound

Product 1

HCID 59574214HCID 59574214, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[1-(Pyrimidin-4-yl)propyl]isoindoline-1,3-dione (292 mg, 1.09 mmol) in methanol (2 mL) was stirred with hydrazine monohydrate (153 μL, 3.15 mmol) at room temperature for 16 hours. After completion of the reaction, the solid was filtered off with chloroform, and the filtrate was evaporated under reduced pressure repeatedly to give the desired product (84% yield).

Workup

  1. customAfter completion of the reaction
  2. filtrationthe solid was filtered off with chloroform
  3. customthe filtrate was evaporated under reduced pressure repeatedly

Sources & evidence

ORD record
ord-23d44a539f5d42379ff9584c078b4e5f
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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