Hydrazine hydrate (1:1) → HCID 55285382, compound

HRID 2092035Notes

Reaction equation

HRID 2092035 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([N:10]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:8][CH3:9])=[CH:3][N:2]=1.O.NN>CO>[N:1]1[CH:6]=[CH:5][C:4]([CH:7]([NH2:10])[CH2:8][CH3:9])=[CH:3][N:2]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59574232HCID 59574232, compound

Product 1

HCID 55285382HCID 55285382, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

2-[1-(Pyridazin-4-yl)propyl]isoindoline-1,3-dione (91.8 mg, 0.34 mmol) in methanol (1 mL) was mixed with hydrazine monohydrate (83 μL, 1.7 mmol) at room temperature and stirred at 60° C. for 3 hours. After completion of the reaction, the solid was filtered off with chloroform, and the filtrate was evaporated under reduced pressure repeatedly to give the desired product (100% yield).

Workup

  1. customAfter completion of the reaction
  2. filtrationthe solid was filtered off with chloroform
  3. customthe filtrate was evaporated under reduced pressure repeatedly

Sources & evidence

ORD record
ord-c5a670413a6d46a28a05aa50b0d7f44f
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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