Hydrazine hydrate (1:1) → HCID 55285530, compound

HRID 2092037Notes

Reaction equation

HRID 2092037 reaction equation
[O:1]=[C:2]1[C:7]([CH2:8][N:9]2C(=O)C3C(=CC=CC=3)C2=O)=[CH:6][CH:5]=[N:4][NH:3]1.O.NN>CO>[NH2:9][CH2:8][C:7]1[C:2](=[O:1])[NH:3][N:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 595748041H-Isoindole-1,3(2H)-dione, 2-[(2,3-dihydro-3-oxo-4-pyridazinyl)methyl]-

Product 1

HCID 55285530HCID 55285530, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

2-[(3-Oxo-2,3-dihydropyridazin-4-yl)methyl]isoindoline-1,3-dione (255 mg, 1.00 mmol) in methanol (2 mL) was mixed with hydrazine monohydrate (250 mg, 5.00 mmol) at room temperature and stirred at 60° C. for 3 hours. After completion of the reaction, the solid was filtered off with chloroform, and the filtrate was evaporated under reduced pressure repeatedly to give a crude reaction product containing the desired product, which was used for the next step.

Workup

  1. customAfter completion of the reaction
  2. filtrationthe solid was filtered off with chloroform
  3. customthe filtrate was evaporated under reduced pressure repeatedly
  4. customto give a crude
  5. customreaction product

Sources & evidence

ORD record
ord-89079f8daeeb463581cb0b7bed38ea0a
Source dataset
uspto-grants-2013_05
Patent number
US08440666B2

Reaction notes

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